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Papers in Refereed Journals (selected from over 100 papers):

Yuko Kurosawa, Ton J. DeGrauw, Diana M. Lindquist, Victor M. Blanco, Gail J. Pyne-Geithman, Takiko Daikoku, James B. Chambers, Stephen C. Benoit and Joseph F. Clark Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency

M.R. Skelton, T.L. Schaefer, D.L. Graham, T.J. deGrauw, J.F. Clark, M.T. Williams and C.V. Vorhees. Creatine Transporter (CrT; Slc6a8) Knockout Mice as a Model of Human CrT Deficiency. PLoS ONE 6(1) 2011, e16187. doi:10.1371/journal.pone.0016187.

S. Hou, R. Xu, J.F. Clark, W.L. Wurster, S. Heinemann, T. Hoshi. Bilirubin oxidation end products (BOXes) directly alter K+ channels important in regulation of vascular tone. J Cereb Blood Flow Metab. 2010 Apr 28.

Y. Kurosawa, A. Lu, P. Khatri, J.A. Carrozzella, J.F. Clark, J. Khoury, T.A. Tomsick. Intra-arterial Iodinated Radiographic Contrast Material Injection Administration in a Rat Middle Cerebral Artery Occlusion and Reperfusion Model: Possible Effects on Intracerebral Hemorrhage. Stroke, May; 41(5):1013-7, 2010. Epub 2010 Apr 1 2010.

J.F. Clark, A. Harm, A. Saffire, S.J. Biehle, A.Lu. and G.J. Pyne-Geithman. Bilirubin Oxidation Products Seen Post Subarachnoid Hemorrhage Have Greater Effects on Aged Rat Brain Compared to Young. Acta Neurochir Suppl 2011; 110: 157-162.

M.C. Loftspring, H.L Johnson, R. Feng, A.J. Johnson and J.F. Clark. Unconjugated Bilibubin Contributes to Early Inflammation and Brain Injury after Intracerebral Hemorrhage. J of Cerebral Blood Flow and Metabolism, November 24, 2010.

A. Lu, Y. Kurosawa, K. Luskey, G. Pyne-Geithman, D. Caudell, J.F. Clark. Hemorrhagic profile of the fibrinolytic alfimeprase after ischemia and reperfusion. PMID: 19298764. Neurol Res. 2:209-214, 2009.

G. Pyne-Geithman, D.N. Caudell, P. Prakash and J.F. Clark. Glutathione peroxidase and subarachnoid hemorrhage: implications for the role of oxidative stress in cerebral vasospasm. Neurol. Res. 2:195-199, 2009. PMCID: PMC2741137.

M.C. Loftspring, J. McDole, A. Lu, J.F. Clark and A.J. Johnson. Intracerebral hemorrhage leads to infiltration of several leukocyte populations with concomitant pathophysiological changes. J. of Cerebral Blood Flow and Metabolism 1:137-143, 2009. PMCID: PMC2710977.

M.C. Loftspring, C. Hansen and J.F. Clark. A novel brain injury mechanism after intracerebral hemorrhage: The interaction between heme products and the immune system. Medical Hypotheses 74: 63-66, 2010. PMCID: PMC2787807.

J. Ellis, R. Grimm, J.F. Clark, G.J. Pyne-Geithman, S. Wilbur, J.A. Caruso. Studying Protein Phosphorylation in Low MW CSF Fractions with capLC-ICPMS and nanoLC-CHIP-ITMS for Identification of Phosphoproteins. J. Proteome Research, 2008.

M.C. Loftspring, J. McDole, A. Lu, J.F. Clark, A.J. Johnson.  Intracerebral hemorrhage leads to infiltration of several leukocyte populations with concomitant pathophysiological changes. J. of  Cerebral Blood Flow & Metabolism. (2008) 1-7.

G.J. Pyne-Geithman, D.N. Caudell, M. Cooper, J.F. Clark, L.A. Shutter.  Dopamine D2-Receptor-Mediated Increase in Vascular and Endothelial NOS Activity Ameliorates Cerebral Vasospasm After Subarachnoid Hemorrhage In Vitro.  Neurocritical Care, 2008

L.M. Brewster, S. van Bree, J.C. Reijneveld, N.C. Notermans, W.M. Verschuren, J.F. Clark, G.A. van Montfrans, M. de Visser.  Hypertension in idiopathic hyperCKemia.  J Neurol. 2008 Jan;255(1):11-5. Epub 2008 Jan 22. PMID: 18204808.

Lu, J.F. Clark, J.P. Broderick, G.J. Pyne-Geithman, K.R. Wagner, R. Ran, P. Khatri, T. Tomsick, F.R. Sharp. Reperfusion activates metalloproteinases that contribute to neurovascular injury. Exp Neurol. 2008 Apr;210(2):549-59. Epub 2007 Dec 15. PMID: 18187134.

J.F.Clark, M.C. Loftspring, W.L. Wurster, G.J. Pyne-Geithman. Chemical and Biochemical oxidations in spinal fluid after subarachnoid hemorrhage.   Frontiers in Bioscience 13: 1806-1812, 2008.

G.J. Pyne-Geithman, S.G. Nair, D.N. Caudell, J.F.Clark.  PKC and Rho in vascular smooth muscle: Activation by BOXes and SAH CSF.  Frontiers in Bioscience 13: 1526-1534, 2008.

W.L. Wurster, G.J. Pyne-Geithman, I.R. Peat and J. F. ClarkBilirubin Oxidation Products (BOXes): Synthesis, Stability and Chemical Characteristics.  Acta Neurochir Suppl 104: 43-50, 2008.

M.C. Loftspring, W.L. Wurster, G.J. Pyne-Geithman, J.F. Clark.  An in vitro model of aneurysmal subarachnoid hemorrhage: oxidation of unconjugated bilirubin by cytochrome oxidase. J Neurochem.,102(6): 1990-1995, 2007.

M.C. Loftspring, J.F. Clark, K.R. Wagner. A novel duplex ELISA method for quantitation of plasma proteins in areas of brain edema. Brain Res. 1162: 130-132, 2007.

P.R. Bhadri, V.A. Salgaonkar, G.J. Pyne-Geithman, J. Caffery, Jr., R. Shukla, F.R. Beyette, Jr., J.F. Clark. Spectrophotometric quantification of bilirubin in hemorrhagic spinal fluid using an innovative algorithm. Med. Chem., 3: 21-27, 2007.

L.M. Brewster, G. Mairuhu, N.R. Bindraban, R.P. Koopmans, J.F. Clark, G.A. van Montfrans. Creatine kinase activity is associated with blood pressure. Circulation, 19: 2034-9, 2006.

J.F. Clark, A. Doepke, J.A. Filosa, R.L. Wardle, A. Lu, T.J., Meeker, G.J. Pyne-Geithman. N-Acetylaspartate as a reservoir for glutamate. Journal of Medical Hypothesis. May 67: (3) 506-12, 2006

Y. Tang, H. Xu, X. Du, L. Lit, W. Walker, A. Lu, R. Ran, J.P. Gregg, M. Reilly, A. Pancioli, J.C. Khoury, L.R. Sauerbeck, J.A. Carrozzella, J. Spilker, J.F. Clark, K.R. Wagner, E.C. Jauch, D.J. Chang, P. Verro, J.P. Broderick, F.R. Sharp. Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. Journal of Cerebral Blood Flow & Metabolism, Aug 26 (8): 1089-102 2006

F.R. Sharp, J.F. Clark.  Bilirubin Oxidation Products (BOXes) and their role in Cerebral Vasospasm Following Subarachnoid Hemorrhage. Journal of Cerebral Blood Flow & Metabolism. 2006 Oct;26(10):1223-33

M. L Field, O. Khan, J. Abbaraju, J.F. Clark. Functional compartmentation of glycogen phosphorylase with creatine kinase and Ca2+ATPase in skeletal muscle. Journal of Theoretical Biology. 238; 257-268, 2006.

G. J. Pyne-Geithman, C. J. Morgan, E. M. Dulaney, J. Carrozzella, D. S. Kanter, K. Wagner, M. Zuccarello, and J.F. Clark. Bilirubin Production and Oxidation in CSF of Patients with Cerebral Vasospasm after Subarachnoid Hemorrhage. Journal of Cerebral Blood Flow and Metabolism; 25:1070-7 2005.

J.F. Clark and G.J. Pyne-Geithman. Vascular smooth muscle function: The physiology and pathology of vasoconstriction. Pathophysiology. 12; 35-47, 2005. Invited Review.

A. Newmeyer, M. Schapiro, K.M. Cecil, J.F. Clark, T.J. deGrauw. Incidence of Brain Creatine Transporter Deficiency in Males with Developmental Delay Referred for Brain Magnetic Resonance Imaging. Journal of Developmental Behavior Pediatrics. 26: 276-282. 2005.

C.J. Morgan, G.J. Pyne-Geithman, E.C. Jauch, R. Shukla, K.R. Wagner, J.F. Clark, and M. Zuccarello. Bilirubin as a Cerebrospinal Fluid Marker of Sentinel Subarachnoid Hemorrhage: A Preliminary Report in Pigs. Journal of Neurosurgery. 101; 1026-1029, 2004.

M.A. Lyons, R. Shukla, K. Zhang, G.J. Pyne, M. Singh, S.J. Biehle, J.F. Clark. Increase of metabolic activity and disruption of normal contractile protein distribution by bilirubin oxidation products in vascular smooth muscle cells. Journal of Neurosurgery 100; 505-511, 2004.

S.J. Biehle, J. Carrozzella, R. Shukla, J. Popplewell, M. Swann, N. Freeman and J.F. Clark. Isoprotein Specific Interactions of Apolipoprotein E with Tissue Plasminogen Activator. Biochimica et Biophysica Acta 1689; 244-251, 2004.

G.J. Pyne, K.M. Cecil, G. Chuck, T.J. deGrauw, M.A. Lyons, Y. Ishida, and J.F. Clark. The Presence Of Normal Creatine In The Muscle Of A Patient With A Mutation In The Creatine Transporter: A Case Study. Molecular and Cellular Biochemistry 263; 35-39, 2004.

S. Jain, K. Jayasimhulu and J. F. Clark. Metabolomic Analysis of Molecular Species of Phospholipids from Normotensive and Preeclamptic Human Placenta Electrospray Ionization Mass Spectrometry. Frontiers in Bioscience 9; 3167-3175, 2004

S. Nakayama, H. Nomura, L.M. Smith, J.F. Clark, and T. Uetani. Mechanisms for Monovalent Cation-Dependent Depletion of Intracellular Mg2+:Na+-Independent Mg2+ Pathways in Guinea-Pig Smooth Muscle. Journal of Physiology 515; 842-853, 2003.

K.R. Wagner, F.R. Sharp, T.D. Ardizzone, A. Lu, J.F. Clark. Heme and iron metabolism: role in cerebral hemorrhage. Journal of Cerebral Blood Flow and Metabolism. 23; 629-52, 2003.

A. Lu, Y. Tang, R. Ran, J.F. Clark, B.J. Aronow, F.R. Sharp. Genomics of the Periinfarction Cortex After Focal Cerebral Ischemia. Journal of Cerebral Blood Flow and Metabolism. 23; 786-810, 2003.

K.M. Cecil, T.J. DeGrauw, G.S. Salomons, J.C. Egelhoff, J.F. Clark. MR Spectroscopy in a Nine-day-old Heterozygous Girl of Creatine Transporter Deficiency. Journal of Computer Assisted Tomography 27; 44-47, 2003.

R.B. Kreider; E.R. Burke; J.F. Clark; C. Earnest; M. Greenwood; R. Harris; D.S. Kalman; S.M. Kleiner; E. Serrano; J.S. Volek; T.N. Ziegenfuss; D.S. Willoughby. The Neurosurgeon in Sport: Awareness of the Risks of Heatstroke and Dietary Supplements. Neurosurgery 52; 252-257, 2003.

G.J. Pyne, TAD Cadoux-Hudson and J.F. Clark. Platelets play an essential role in the etiology of cerebral vasospasm after subarachnoid hemorrhage. Medical Hypothesis 60, 525-530, 2003.

S. Nakayama and J.F. Clark. Smooth Muscle and NMR Review: NMR Overview of Smooth Muscle Metabolism. Molecular and Cellular Biochemistry 244, 17-30 2003.

J.F. Clark, M. Reilly, F. R. Sharp. Oxidation of Bilirubin Produces Compounds that Cause Prolonged Vasospasm of Rat Cerebral Vessels: A Contributor to Subarachnoid Hemorrhage Induced Cerebral Vasospasm. Journal of Cerebral Blood Flow and Metabolism 22; 472-478, 2002.

J.F. Clark, DA Huri, J. Carrozzella, E. C. Jauch, P Mehta, S. J. Biehle, F. R. Sharp, and J.P. Broderick. Isoforms of Apolipoprotein E Can Modulate tPA Induced Clot Lysis In Vitro. Frontiers in Bioscience 7; a163-168, 2002.

S. Nakayama, H. Nomura, L. M. Smith and J.F. Clark. Simultaneous Estimation of Intracellular Free Mg2+ and pH Use of a New pH-dependent Dissociation Constant of MgATP. Japanese Journal of Physiology 52; 323-326, 2002.

Lu, A R. Ran J.F. Clark, M Reilly, A. Nee and F.R. Sharp. 17-b-Estradiol Induces Heat Shock Proteins in Brain Arteries, and Potentiates Ischemic Heat Shock Protein Induction in Glia and Neurons. Journal of Cerebral Blood Flow and Metabolism. 22; 183-195, 2002

G.J. Pyne T.A.D. Cadoux-Hudson, J.F. Clark. Magnesium Protects Against Subarachnoid Haemorrhage Induced Cerebral Vasospasm In Vitro. British Journal of Neurosurgery, 15;409-415 2001.

J.F. Clark, G.J. Pyne, O.J. Choutka, J.A. Carrozzella, J. Khoury, J.P. Broderick, and T.A.D. Cadoux-Hudson. In Vitro Therapy with Dobutamine, Isoprenaline and Sodium Nitroprusside Protects Vascular Smooth Muscle Metabolism from Subarachnoid Hemorrhage Induced Cerebral Vasospasm. Acta Neurochirurgica 143;721-728 2001.

G.J. Pyne, T.A.D. Cadoux-Hudson, and J.F. Clark. Cerebrospinal Fluid from Subarachnoid Haemorrhage Patients Causes Excessive Oxidative Metabolism Compared to Vascular Smooth Muscle Force Generation. Acta Neurochirurgica 143; 59-63, 2001

T.A.D. Cadoux-Hudson, G.J. Pyne, Z. Domingo, and J.F. Clark. The Stimulation, of Vascular Smooth Muscle Oxidative Metabolism by CSF from Subarachnoid Haemorrhage Patients Increases with Fisher and WFNS Grades. Acta Neurochirurgica 143; 65-72, 2001

K.R. Kranc, G.J. Pyne, L. Tao, T.D.W. Claridge, D.A. Harris, T.A.D. Cadoux-Hudson, J.J. Turnbull, C.J. Schofield and J.F. Clark. Oxidative Degradation of Bilirubin Produces Vasoactive Compounds. European Journal of Biochemistry. 267; 7094-7101 2000.

N.F. Thomson, S. Thornton, and J.F. Clark. The Effects of Placental Extracts from Normotensive and Preeclamptic Women on Vasoconstriction and Oxidative Metabolism. American Journal of Obstetrics and Gynecology. 183; 206-210, 2000.

G.J. Pyne, T.A.D. Cadoux-Hudson and J.F. Clark. An Extractable Phosphatase Inhibitor is Present in the CSF of Subarachnoid Hemorrhage Patients with Vasospasm. Biochimica et Biophysica Acta, 1474; 283-290, 2000.

J.F. Clark, G.K. Radda and E.A. Boehm. The Effects of Anti-Hypertensive Therapy on the Structural, Mechanical and Metabolic Properties of the Rat Aorta. Journal of Muscle Research and Cell Motility. 21; 255-267, 2000.

L.M. Brewster, J.F. Clark, G.A. van Montfrans. Is Greater Tissue Activity of Creatine Kinase The Genetic Factor Increasing Hypertension Risk in Black People of Sub-Saharan African Descent? Journal of Hypertension. 18; 1537-1544, 2000.

J.F. Clark, T. Matsumoto and S. Nakayama. Intact Smooth Muscle Metabolism: Its Responses to Cyanide Poisoning and Pyruvate Stimulation. Frontiers in Bioscience 5a; 18-23, 2000.

T.A.D. Cadoux-Hudson, G.J. Pyne, and J.F. Clark. Subarachnoid Haemorrhage Induced Cerebral Vasospasm: A Subcellular Perspective on the Control of Tension. Emerging Therapeutic Targets. 3; 439-452, 1999.

J.F. Clark and K.R. Kranc, The Role of the Mitochondrion in Smooth Muscle Cell Fate Choices of Proliferation Versus Apoptosis During Vascular and Cardiovascular Disease. Emerging Therapeutic Targets. 3; 513-525, 1999.

W.S. Kunz, A.V. Kuznetsov, J.F. Clark, I. Tracey, and C.E. Elger. Metabolic consequences of the cytochrome c oxidase deficiency in brain of copper-deficient Movbr mice. Journal of Neurochemistry. 72; 1580-1585, 1999.

M.C. Bearchell, C.W.G. Redman, G.J. Pyne, T.A.D. Cadoux-Hudson, and J.F. Clark. Vascular Smooth Muscle Oxygen Consumption is Reversibly Stimulated by Sera from Women with Pre-Eclampsia. American Journal of Obstetrics and Gynecology. 179; 1534-1538, 1998.

J.F. Clark. Creatine: A Review of its Nutritional Applications in Sport. Journal of Nutrition, 14; 322-324, 1998.

G.J. Kemp, D.N. Manners, J.F. Clark, M.E. Bastin, and G.K. Radda. Theoretical modelling of some spatial and temporal aspects of the mitochondrion/creatine kinase/myofibril system in muscle. Molecular Cell Biochemistry. 184; 249-289, 1998.

J.F. Clark,A.V. Kuznetsov, and G.K. Radda. ADP Regenerating Enzyme Systems in the Mitochondria of the Guinea Pig Myometrium and Heart. American Journal of Physiology, Cell Physiology. 41; C399-C404, 1997.

S. Nakayama, S. Chihara, J.F. Clark, S.-M. Huang, T. Horiuchi, & T. Tomita. Consequences of metabolic inhibition in smooth muscle isolated from guinea-pig stomach. Journal of Physiology. 505; 229-240, 1997.

J.F. Clark. Creatine and Phosphocreatine: A Review of Their Uses in Exercise and Sport. Invited Review, Journal of Athletic Training. 32;45-51, 1997.

G.J. Kemp, D.N. Manners, J.F. Clark, M.E. Bastin, and G.K. Radda. A theoretical model of some spatial and temporal aspects of the mitochondrion creatine kinase myofibril system in muscle. Molecular Cell Biochemistry 174; 29-32, 1997.

M.L. Field, and J.F. Clark. Inappropriate Ubiquitin Conjugation: A Proposed Mechanism Contributing to Heart Failure. Cardiovascular Research, 33; 8-12, 1997.

E.A. Boehm, G.K. Radda, H. Tomlin, and J.F. Clark. Utilisation of Creatine and its Analogues by Cytosolic and Mitochondrial Creatine Kinase. Biochimica et Biophysica Acta, 1274; 119-128, 1996.

A.V. Kuznetsov, J.F. Clark, K. Winkler and W.S. Kunz. Change in Flux Control Coefficient of Cytochrome C Oxidase in Copper Deficient Mottled Brindled Mice. Journal of Biological Chemistry, 271; 283-288, 1996.

B. Leighton, A. Sanderson, M. Young, G.K. Radda, E. Boehm, and J.F. Clark. Effects of Treatment of Spontaneously Hypertensive Rats with the Angiotensin Converting Enzyme Inhibitor Trandolapril on the Sensitivity of Glucose Metabolism to Insulin in Isolated Incubated Soleus Muscle Preparations. Diabetes, 45; S120-S124, 1996

E. A. Boehm, J. F. Clark, and G. K. Radda. Metabolite Utilization and Possible Compartmentation in Porcine Carotid Artery: A Study Using b-Guanidinopropionic Acid. American Journal of Physiology, 268; C628-C635, 1995.

J.F. Clark, and P.F. Dillon. Phosphocreatine and Creatine Kinase in Energetic Metabolism of the Porcine Carotid Artery. Journal of Vascular Research, 32; 24-30, 1995.

P.F. Dillon, M.K Weberling, S.M. LeTarte, J.F. Clark, P.M. Sears and R.S. Root-Bernstein. Creatine Kinase Increases the Solubility and Enzymatic Activity of Pyruvate Kinase by Means of Diazymatic Coupling. Journal of Biological Physics, 21; 11-23, 1995.

J.F. Clark, G.J. Kemp and G.K. Radda. The Creatine Kinase Equilibrium, Free [ADP] and Myosin ATPase in Vascular Smooth Muscle Cross-Bridges. Journal of Theoretical Biology, 173; 207-211, 1995.

J.F. Clark, Z. Khuchua, A.V. Kuznetsov, L. Vasilyeva, E. Boehm, G.K. Radda and V. Saks. Actions of the Creatine Analogue b-Guanidinopropionic Acid on Rat Heart Mitochondria. Biochemical Journal, 300; 211-216, 1994.

J.F. Clark, A.V. Kuznetsov, Z. Khuchua, V. Veksler, R. Ventura-Clapier, and V.A. Saks. Creatine Kinase Function in Mitochondria Isolated from Gravid and Non-Gravid Guinea-Pig Uteri. FEBS Letters, 347;147-151, 1994.

J.F. Clark. The Creatine Kinase System in Smooth Muscle. Molecular and Cellular Biochemistry, 133/134; 221-232, 1994.

J.F. Clark, Z. Khuchua, A.V. Kuznetsov, E. Boehm and R. Ventura-Clapier. Creatine Kinase Activity Associated with the Contractile Proteins of the Guinea Pig Carotid Artery. Journal of Muscle Research and Cell Motility, 15; 432-439, 1994.

M.L. Field, J.F. Clark, C. Henderson, A-M Seymour, and G.K. Radda. Alterations in the Myocardial Creatine Kinase System During Chronic Anaemic Hypoxia. Cardiovascular Research, 28; 86-91, 1994.

J.F. Clark, Z. Khuchua, A.V. Kuznetsov, V.A. Saks, and R. Ventura-Clapier. The Compartmentation and Role of Creatine Kinase in the Myometrium of the Gestating Guinea Pig Uterus. Journal of Physiology, (London), 466; 553-572, 1993.

E.V. Vasil'eva, Iu.O. Belikova, S.A. Liapina, L.E. Petrova, A.V. Kuznetsov, N.A. Perov, J.F. Clark, V.A. Saks. The Possible Role of the Inner Mitochondrial Membrane in Regulating Oxidative Phosphorylation in Cells in vivo. Biochimiia (Russia), 58; 1742-1754, 1993.

J.F. Clark, Z. Khuchua, and R. Ventura-Clapier. Creatine Kinase Binding and Possible Role in Chemically Skinned Guinea Pig Taenia Coli. Biochimica et Biophysica Acta, 1100; 137-145, 1992.

Z. Khuchua, A.V. Kuznetsov, E.V. Vasilyeva, R. Ventura-Clapier J.F. Clark, A. Steinshneider, O.V. Korchazhkina, V.L. Lakomkin, T. Branishte, E.K. Ruuge, V.I. Kapelko, and V.A. Saks. The Creatine Kinase System and Cardiomyopathy. The American Journal of Cardiovascular Pathology, 4; 223-233, 1992.

D. McKeag, B. Smith, R. Edminster, T. Laird, J.F. Clark, and S. Herron; Estimating the Severity of Osteoarthritis with Nuclear Magnetic Resonance Technology. Seminars in Arthritis and Rheumatism, 21; 227-238, 1992.

J.F. Clark, G.I. Harris, and P.F. Dillon. Multisite Saturation Transfer Using DANTE and Continuous Wave. Magnetic Resonance In Medicine, 17; 274-278, 1991.

P.F. Dillon and J.F. Clark. The Theory of Diazymes and functional Coupling of Pyruvate Kinase and Creatine Kinase. Journal of Theoretical Biology, 143; 275-284, 1990.

J.F. Clark, and P.F. Dillon. Contractile and Metabolic Effects of TMSPS on Vascular Smooth Muscle. Biochimica et Biophysica Acta, 1014; 235-238, 1989.


Books Published:

My Ambulance Education: Life and Death in the Streets of the City. J.F. Clark.  Firefly Books c, 2009.

Guanidino Compounds in Biology and Medicine 5th Edition.
Eds.: A. Mori, M. Ishida and J.F. Clark. Blackwell Publishers (Eastleigh, UK), 1999.

Creatine & Creatine Phosphate: Scientific and Clinical Perspectives.
Eds.: M. Conway and J.F. Clark. Academic Press (London), 1996.


Book Chapters:

J.F. Clark, G.J. Pyne-Geithman, M. A. Lyons, S. J. Biehle and F.R. Sharp. Bilirubin Oxidation Products and their role in Subarachnoid Hemorrhage Induced Cerebral Vasospasm. Cerebral Vasospasm: Advances in Research and Treatment. Ed: R. Loch MacDonald. 51-57, Thieme, New York, 2004.

G.J. Pyne-Geithman, S. Nakayama, T.A.D. Cadoux-Hudson, and J.F. Clark. Magnesium and Cerebral Vasospasm. Cerebral Vasospasm: Advances in Research and Treatment. Ed: R. Loch MacDonald. 156-159, Thieme, 2004.

R. Ran, A. Lu, J. Clark, F. Sharp. Heat shock protein protection in brain using the HSP90 binding drug geldanamycin. Pharmacology of Cerebral Ischemia.” Eds J. Krieglstein, S. Klumpp, 471-485, 2002.

J.F. Clark. Creatine in Cardiovascular Metabolism During Physiological and Pathological Conditions: NMR Studies. “Creatine; from basic science to clinical application.Eds R. Paoletti, A. Poli, and AS Jackson. Klewer; Lorenzini Foundation Publications. Chapter 4, 25-32, 2000

J. F. Clark. Creatine Analogues and Their Actions on Creatine Kinase in vitro and in vivo. “Guanidino Compounds in Biology and Medicine 5th Edition.” Eds. A. Mori, M. Ishida and J.F. Clark. Blackwell Publishers. Chapter 8, 75-90, 1999.

J.F. Clark, and M.L. Field. Creatine, Phosphocreatine and b-Guanidinopropionic Acid: Their Uses in Biochemical and Medical Research. “Guanidino Compounds in Biology and Medicine.”2nd Edition. Eds, De Deyn, Marescau, Stalon and Qureschi; John Libbey and Company Ltd. Chapter 17, 156-142, 1996.

J.F. Clark, The Role of Creatine Kinase in Smooth Muscle. “Guanidino Compounds in Biology and Medicine.” 2nd Edition. Eds, De Deyn, Marescau, Stalon and Qureschi; John Libbey and Company Ltd. Chapter 16, 143-155, 1996.

J.F. Clark. Allenamento Muscolare E Supplementazione Orale Di Creatine. Attivita’ Fisco-Sportiva: Muscolo Scheletrico, Fatica Neuromuscolare Sindrome Da Fatica Cronica. Associazione Nazionale Specialisti in Medicina Dello Sport. 2-5, pp 275-282, July 1995.

A.V. Kuznetsov, J.F. Clark, K. Winkler and W.S. Kunz. Change in Flux Control Coefficient of Cytochrome C Oxidase in Copper Deficient Mottled Brindled Mice. “What is controlling Life?” Eds.: E.Gnaiger, F.N. Gellerich and M. Wyss. 275-278, 1994.

R. Ventura-Clapier, J.A. Hoerter, Z. Khuchua, A.V. Kuznetsov, and J.F. Clark. Perinatal Development of the Creatine Kinase System in Mammalian Heart. "Guanidino Compounds in Biology and Medicine." Eds, De Deyn, Marescau, Stalon and Qureschi; John Libbey and Company Ltd. 195-204, 1992.

P.F. Dillon, M.J. Fisher, G.R. Adams, and J.F. Clark; The Use of 31P-NMR to Study Smooth Muscle. "Muscle Energetics," R.J. Paul, G. Elzinga and K. Yamada. Eds., Alan R. Liss, New York, 339-349, 1989.


Other Publications:

J.F. Clark. Creatine – Performance Enhancer. Biological Sciences Reviews. 12; 23-25. 2000.
J.F. Clark. Creatine and Phosphocreatine: A Review of Their Uses in Exercise and Sport. Journal of Pre-Med Studies. 6:30-37, 1997.

J.F. Clark. Meeting Report: Experimental Biology ’95 (FASEB). The British Society For Cardiovascular Research, Quarterly Bulletin. 8:8-9, 1995.

J.F. Clark. 5000 Physiologists Descend on Glasgow: IUPS Meeting Report. The Biochemist, 15;45-46, 1993.

Quoted in: Elle Magazine. Vegetable Matter. Vol. 226, page 146; June 2004.



  • J.F. Clark, and T.A.D. Cadoux-Hudson. Oxidative Metabolism in Smooth Muscle Cells: Methods and Materials Relating Thereto. EP0898707, 6,284,542.
  • J.F. Clark, C.J. Schofield and T.A.D. Cadoux-Hudson. Degradation Fragments. British Patent issued; BP5651013, 7,098,238
  • J.P. Broderick, J.F. Clark, and D. L. Woo. Methods for Inhibiting the Lysis of Coagulated Blood with Apolipoprotein E4 Phenotype. Issued Patent 7,135,305
  • J.P. Broderick, J.F. Clark, and D. L. Woo. Methods for Enhancing the Lysis of Coagulated Blood with Apolipoprotein E2 Phenotype. Patent Pending. 20040006017
  • R. Kaddurah-Daouk, J.F. Clark, T. DeGrauw. Methods Of Treating Cognitive Dysfunction By Modulating Brain Energy Metabolism. Provisional Patent Filed: Patent Pending. 20060241021.